Tissue/blood collection

MIPPaC: Understanding the mechanisms underlying weight loss in people with cancer by investigating changes to metabolism and the immune system

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Precision-Panc: Advancing personalised medicine treatment strategies for pancreatic cancer

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Pancrea_tive: Investigating tumour-stroma heterogeneity in human pancreatic cancer and pancreatic diseases

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Locally advanced

STARPAC2 (Primus-05): Phase IIb randomised clinical trial repurposing ATRA as a stromal targeting agent in a novel drug combination for pancreatic cancer

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Metastatic - 1st or 2nd line

PRIMUS-001: An adaptive phase II study of FOLFOX-A (FOLFOX and nab-paclitaxel) versus AG (nab-paclitaxel and gemcitabine) in patients with metastatic pancreatic cancer, with integrated biomarker evaluation

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PemOla: A phase II study combining pembrolizumab (anti-PD-1R Ab) with olaparib (PARP inhibitor) in metastatic PDAC patients with mismatch repair deficiency or tumour mutation burden > 4 mutations/Mb

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Metastatic - 2nd line and beyond

ATRiUM: A Phase I clinical trial looking at AZD6738 (ATR inhibitor) in combination with Gemcitabine

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